Arterial occlusions – Ischaemia

Cardiovascular diseases, the leading global cause of death, claims approximately 17.9 million lives each year. The majority of deaths from cardiovascular diseases are attributed to arterial occlusion-related conditions like acute myocardial infarction and ischemic stroke.

Cardiovascular diseases are the leading global cause of death, responsible for approximately 17.9 million deaths annually. Cardiovascular diseases caused by arterial occlusion, such as acute myocardial infarction and ischemic stroke, account for most of these deaths. Arterial occlusions can also occur in extremities, kidneys, or the small intestine, leading to vascular emergencies with critical reductions in blood supply and tissue oxygenation, necessitating prompt intervention. The common causes of arterial occlusion include thrombosis, embolism, and local vasoconstriction, often exacerbated by endothelial dysfunction and diminished nitric oxide (NO) production. In addition, even after blood flow is restored, Ischemia-Reperfusion injury, causing cellular dysfunction and death.

Current treatments for acute arterial occlusion involve clot removal through thrombolytic therapy or mechanical procedures, but they have limitations, including their complexity, time consumption, and potential side effects like bleeding. These treatments often fall short of providing optimal outcomes for patients.

Attgeno intends to clinically investigate the potential of Supernitro in various conditions with arterial occlusions.

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