R&D highlights & background


Attgeno reports first healthy volunteers dosed with Supernitro in phase 1 trial

Attgeno AB today announced that the first 8 healthy volunteers have been successfully dosed in a phase 1 clinical study with the company’s lead drug candidate, Supernitro. The trial continues according to the clinical protocol and will include up to 48 healthy volunteers. Read more

The Supernitro project was granted MSEK 5 in support from Vinnova

Swedish government. research fund Vinnova grants Attgeno MSEK 5 for a Phase 2a study in critically ill Covid-19 patients with pulmonary hypertension.

Second financial round oversubscribed rights issue

Attgeno completes second rights MSEK 20, oversubscribed with 49%

Clinical phase 1 FIH study approved by Swedish MPA

New NO-donating substances

In the spring, Attgeno initiated a project to further explore the possibility to synthesize and test a number of new NO-donating substances. Company had the goal to identify 3-5 new substances, but in the end, we have now synthesized 10 new drug candidates.

First financial round – oversubscribed rights issue

Attgeno completes a first rights issue of 30 million SEK and previous loans are converted to new shares. The Attgeno board of directors is renewed to strengthen competence regarding business and pharmaceutical development. 

In autumn 2018, the Supernitro project was granted 5 million SEK in support from SweLife, (Swedish government research fund).

Tox studies collaboration

Toxicological MTD and 2-week daily repeated dose studies are carried out in collaboration with Swetox (RISE), Sweden and Accelera in Italy. The tox studies are done in rodents and non-rodents (rats and dogs) with excellent results regarding safety. 

Supported by Karolinska Institute

The company is supported with grants from Karolinska Institute Innovation AB to promote business development.The company adopts a clear strategy developing Supernitro for the treatment of acute Pulmonary Hypertension. 

Funds for intensified development are provided through a convertible loan and soft money from the Novo Nordic Foundation, SweLife and Karolinska Innovation.

Supernitro patented

Attgeno AB receives patent protection for both the method of generating new compositions and substance patents for Supernitro.

Attgeno registered

Attgeno AB is registered to facilitate the commercial development of the new concept for creating new NO donating compositions. 

Patent development is funded by own resources and in part by the company Aerocrine who receives the rights of Attgeno´s patent application for the diagnosis of pulmonary embolism. Attgeno wins the first prize in Karolinska Institute’s innovation competition.

The start

Professor Lars Gustafsson and Magnus Persson discover that endogenous NO can be measured in the exhaled air in animals and humans. 

The research group launches a comprehensive program to study the importance of NO in the pulmonary and cardiovascular systems and the potential of the discovery of NO for future diagnostics and therapy. 

Christofer Adding and Per Agvald and towards the end of the period Kristofer Nilsson. Dag Linnarsson is linked to the group through different research collaborations. Disease animal models for various types of Pulmonary hypertension e.g pulmonary embolism are developed. It is concluded that NO can counteract Pulmonary Hypertension and increase survival. 

A new method to create compositions capable of delivering NO via intravenous infusion is formulated and the patent processes begin.


Development background